Wednesday, 12 November 2014

Neuroanesthesia


A close association of Neurosurgeon and neuroanesthesia is mandatory for good clinical outcome of neurosurgical patients. The anesthesia for neurosurgery aincludes anesthesia for surgical procedures for diseases of brain and spine. Neuroanesthesia is different from anesthesia for other surgical procedures. Although any trained anesthetist can pusue a career in the field of neuroanestheasia , there is need to develop acumen of identifying early, minute and subtle changes in the parameters of the neurosurgical patient before, during and after the neurosurgical procedure. In addition,  neuroanesthetist should be prompt to respond to these changes. 
Preanesthetic checkup (PAC) requires anesthetist to be knowledgeable about the common CNS diseases and their possible impact. A knowledge about different surgical approaches, positioning and monitoring of the patient during and after surgery is mandatory for a neuroanesthetist. A neuroanesthetist is not just a passive observer of the surgery but is a important team member who actively coordinates the entire process of anesthesia care. Neuroanesthesist knows how the surgical procedure is being carried out. The neuroanesthetist’s  approach should not be antagonistic to the surgeon but should complement the effort of the neurosurgeon.

Neuroanesthetist should have a vision about the entire neurosurgical procedure so the involvement of neuroanesthetist begings much before the start of actual neurosurgical procedure. So, somebody decides to become neuroanethetist it seems that person has decided to be team person and ready to contribute to patient’s care without being in limelight. Neuroanesthesist plans the positioning, mode of intubation, induction & maintenance of anesthesia, taking care of co-morbidities in a patient , and foresees the unexpected complications.
Prevention of possible positioning injuries during the lengthy neurosurgical procedure should be done before draping of the patient. Care of pressure over the orbits, covering of the eyes and exposure to cornea, pressure over the peripheral nerves, should always be done

Neuranesthetist needs to make extra effort during surgery for degenerative spine, Transoral odontoidectomy, transnasal transsphenoidal surgery, awake craniotomy, sitting position, elective hyperventilation, pediatric neurosurgery , functional neurosurgery and many other neurosurgical procedures. Neuroanesthetist should speculate and take necessary steps for anticipated blood loss, vasospasm, brain retarction, brain edema during  surgery. Cerebral protection during neurosurgery should be the priority of the neuroanesthetist.

Some basic facts: 

Intracranial Pressure (ICP), Cerbral Perfusion Pressure  (CPP), Cerebral Blood Flow (CBF), Cerebral Metaboloc Rate of Oxygen Consumption ( CMRO2) are important parameters which are modified by blood pressure (BP0, jugular venous pressure (JVP),  Partial pressure of arterial carbon di-oxide or arterial CO2 tension (PaCO2), Hematocrit, blood Glucose level, elevation of the head of the patient, intravascular volume.  

Blood pressure determines CPP. Neuroanesthetist manipulates CPP according to patient’s needs. CPP is reduced when neurosurgeon is working on an aneurysm, or increased during cross clamping to enhance collateral circulation. The measurement of BP by arterial line is most accurate and it should be calibrated at the external auditory meatus to most closely reflect ICP.  So, all neuroanesthetists should be able to put intrarterial line prior to neurosurgical procedures where strict monitoring of BP is mandatory. Common stites of intraarterial line in neurosurgery is the Dorsalis Pedis Artery over the dorsum of the foot. This intrarterial line is removed after neurosurgical procedure is over.

Jugular venous pressue (JVP) also influences intracranial pressure (ICP).

Quickenstedt  established the range of normal ICP and demonstrated the effect of changes in body position and respiration . Lundberg, in 1960, described the 3 ICP waveforms.
Cranium is like a rigid bony sphere with a constant intracranial volume and it contains three components

1. Brain    1400 mL

2. CSF       150 mL

3. Blood    150 mL
Therefore, any change in the volume of the brain causes a reciprocal change in the volume of other intracranial components, i.e., either blood or CSF.  This is the basis of Monro-Kellie hypothesis introduced in neurosurgery by Cushing.


There is a relationship between  intracarnial volume and intracranial pressure.  Because cranium  is  a rigid and non-distensible structure, any increase in the volume of a component would be accompanied by a reciprocal decrease in the volume of the other two components. Once the volume buffering capacity is exhausted, the ICP would begin to rise.
During gradual expansion of a mass lesion, the volume displaced may be CSF, intravascular blood or brain tissue water. Of the three components, CSF appears to be the main buffer and is the first to be displaced as evident  by compressed ventricles  and obliterarted subarachnoid spaces.


The rate of expansion of an intracranial mass is also important. A rapidly growing intracranial mass lesion may outpace the compensatory shift of CSF and even the smallest increase in mass could produce a life threatening increase in ICP. Thus, a large hematoma could be accommodated within a few hours without dangerous rise in ICP.

Intracranial hypertension can lead to secondary changes by interfering with the cerebral blood flow ( CBF). The normal  cerebral blood flow ( CBF) is about 50 mL/100 gram of brain/min.

Cerebral Perfusion Pressure ( CPP) is defined as the difference between mean arterial pressure
( MAP) and intranial pressure (ICP).

CPP= MAP-ICP

Normal range of ICP in an adult is less than 10-15 mmHg.
Cerebral perfusion pressure is normal till the autoregulation mechanism of brain is intact. But there is a range upto which level body is able to maintain CPP.  Between 60 to 160 mmHg of mean arterial pressure brain will be able to receive blood with normal perfusion. But, if MAP falls blow 50 mmHg, features of cerebral ischemia will appear.
Mean Arterial Pressure ( MAP)= Diastolic Pressure+1/3rd of Pulse Pressure 
Pulse pressure= Systolic blood pressure - Diastolic pressure
So, in a normal person MAP = 80 mmHg+ (120mmHg-80mmHg)/3
MAP= 80+40/3
So on average, roughly MAP is about 90-95.

A rise in ICP would lead to a fall in CPP unless buffered by a compensatory rise in blood pressure ( Cushing response). Raised ICP can cause hypertension, bradycardia and respiratory changes. Therefore any patient who is suspected as a case of intracranial space occupying lesion ( ICSOL), like brain tumor or hematoma or granuloma or abscess and complaining of headache, vomiting, blurring of vision then blood pressure and pulse rate should always be monitored. In clinical setting bradycardia is a reliable indicator of rise in ICP in a patient who was otherwise allright sometimes back. Bradycardia is a sign of raised ICP and can precede and appears before deterioration of conscious level ( Drowsinees, disorientation or poor Glasgow Coma Scale) and papillary asymmetry.

Lundberg described three pressure waves namely A waves, B waves and  C waves .
A waves
A waves are pathological  and indicate rapid rise in ICP  for variable period and then rapid fall to the baseline.
The A waves that persist for longer periods( usually 5-20 minutes) are called plateau waves.
Smaller A waves termed “ atypical” or “ truncated” A waves , that often do not exceed an elevation of 50 mm Hg, are also clinically important early indicators of neurological deterioration.

The A waves are accompanied by clinical features  of raised ICP, like headache, vomiting, decerebrate posturing, papillary changes, bradycardia and hypertension and respond to CSF drainage, hyperventilation and osmotic diuretics.

B waves
Occur at the rate of 0.2-2 per minute and are related to respiration.
B waves may be vasomotor in origin. Lundberg initially described them in patients with intracranial hypertension, though they can occur in normal individuals.
B waves are said to be one of the best predictors of outcome after surgery for normal pressure hydrocephalus.
C waves
C waves are low amplitude with afrequency of 4-8 per minute. These waves are thought to be related to Traube-Hering- Mayer waves.
C waves are of little clinical significance.

There is pressure equilibrium in the skull  but if pressure rises then a part of brain herniates. The herniations are subfalcine, tentorial, and tonsillar. In subfalcine herniation, a part of the frontal lobe herniates below the falx to the opposite side . In tentorial herniation ( Uncal herniation) a part of the medial temporal lobe herniated below through an opening in the tent and compresses over the midbrain. In tonsillar herniation, a part of cerebellum,i.e, Cerebellar Tonsil herniates down through the Foramen Magnum and compresses the medulla oblongata ( Coning). Brain Herniation is life threatening as it causes  brain stem compression which contains vasomotor center. Patient presents with drowsiness, decerebrate posturing, papillary asymmetry, bradycardia, hypertension and respiratory irregularities.

Increased ICP is indicated by a sustained elevation in pressure above 15 mmHg or when intermittent A or B waves are recorded.

The normal CSF pressure measured through the lumbar route ranges from 50 to 200 mm H2O in the lateral decubitus position.

ICP and CPP monitoring are important in the management of head injury patients, especially in whom the decision to operate is equivocal. Surgery may be required if ICP is progressively rising and not responding to conservative treatment with cerebral decongestants. ICP monitoring may also be required in patients of spontaneous subarachnoid hemorrhage (SAH) to assess the effect of cerebral vasospasm and in patients of arrested hydrocephalus and  normal pressure hydrocephalus to take decision about CSF diversion procedure.

Various methods of monitoring the ICP

1.       Intraventricular catheters like External Ventricular Drainage ( EVD): Most accurate, lower cost, also allows therapeutic drainage of CSF

2.       Intraparenchymal catheters (eg. Camino labsor Honeywell/Phillips)

3.       Epidural catheters ( e.g. Fibreoptic tipped catheter: Ladd fireoptic)

4.       Subarachnoid bolt (screw)

5.       Subdural ( eg. Cordis Cup catheter)

Monitoring Systems can broadly be divided into Fluid coupled system and Non-fluid cupled system

In fluid-coupled system a fluid filled catheter or a hollow bolt placed in the ventricle, subarachnoid space or the subdural space connected to a pressure transducer through a fluid-filled line. The transducer converts the hydraulic pressure into an electrical signal which can be displayed  digitally or an oscilloscope.

In Non-fluid coupled systems, the transducer is mounted on the monitoring device itself.

In infants and in children below 18 months of age , the anterior fontanelle is open. Tense anterior fontanelle indicates raised ICP and intraventricular pressure. CSF drainage can be done from the right side lateral angle of the diamond shaped anterior fontanelle.

In clinical setting  cerebral edema is one of the important causes of raised ICP.  if a patient presents with clinical features of raised intracranial pressure, then following steps may be helpful:

Bed rest  reduces the cerebral  metaboloic  rate of oxygen consumption and decreased blood supply

Oxygenation

Elevation of head end of the bed to 30o

Acetazolamide ( Diamox tablet) is a carbonic anhydrase inhibitor and is available in tablet form . In an adult 250 mg tablet can be given orally three times a day( tds)

Frusemide or Furusemide ( Lasix) is a loop diuretic and is available in both oral and injectable form. A dose of 40 mg twice a day reduces the cerebral edema ICP. But Frusemide use may cause  potassium  loss leading to hypokalemia so serum electrolyte monitoring should also be done. To avoid hypokalemia , potassium supplement is advised for example syp Potklor  1 TSF twice a day or Injection KCL  in Intravenous  infusion may be given. Another drug can be prescribed is Spironolactone( Lasilactone), a potassium sparing diuretic and then potassium supplementation is not required.

Injection Mannitol 100 ml stat or 100 ml 8 hourly ( 1 -1.5 Gm/ kg body weight in divided doses in an adult) for three days and then Syp Glycerol 6 TSF three times a day for about 2 weeks.

Dexamethasone 4 mg 6 hourly in injectabe or oral form. Ranitidine or other antacid should be prescribed alog with steroid to avoid gastritis. Dexamethasone is diabetogenic and raises blood sugar level. Prolong  use is associated with fluid retention and swelling over face and body.

CSF drainage is another way to reduce ICP. Ventricular tap is done usually through the point just anterior to the coronal suture on right side , about 3 cm lateral to the sagittal suture . This is a ethod of reducing ICP in a patient with post meningitic hydrocephalus and at the time of surgery. And if CSF pressure is persistently high then External ventricular drainage system can be used.

Elective hyperventilation is a mode or reducing ICP. Hyperventilation leads to CO2 wash out which  causes vasoconstriction and decreased blood supply to the brain leading to decreased ICP. In this procedure patient is intubated after giving muscle relaxant and put on ventilation for about 48 hours. The ventilator mode is Controlled Mechanical Ventilation ( CMV) the respiratory rate is low,i.e., about 16/minute and monitoring of the patient is done with arterial blood gases(ABG) in which the pCO2 is about 25mm Hg ( Normal range of arterial partial pressure of Carbon Dioxide ranges from 25mm Hg to 42 mmHg). Elective hyperventilation is often advise in patients with severe head injury, diffuse axonal injury, in a patient of spontaneous subarachnoid hemorhhage ( SAH) presenting with features of vasospasm, after a prolonged surgery with brain swelling during surgery.

Some surgical ways of reducing ICP are CSF diversion procedures ,  decompressive craniectomy or excision of the intracranial space occupying lesion( ICSOL) like hematoma, tumor or abscess.

Arterial CO2 tension (PaCo2 ) is the most potent cerebral vasodilator and it should optimally be about 30-35. Hyperventilation reduces PaCo2 ( Hypocapnea) which decreases CBV but also CBF. The goal is ideally  end tidal CO2 ( ETCO2)  of 25-30 mm Hg.
Cerebral Metaboloc Rate of Oxygen Consumption (CMR02) is very important can in simple way it can be explained as the metabolic rate of the brain tissue. So, if hypothermia is induced, the brain tissue metabolism will fall and CMR0will decrease.  CMRO2 is also reduced with certain neuroprotective agents. Hypothermia, Phenobarbitone decrease CMRO2 and reduce the harmful effects of ischemia.

Average cerebral blood flow (CBF) in an adult is approximately 50 mL/100 gram of brain per minute.
Auto-regulation is the ability of brain to maintain a constant blood flow over a range of perfusion pressure. Thus, CBF is constant between mean arterial pressure (MAP) of 50-150 mmHg.

Hematocrit or Packed Cell Volume ( PCV)  in neurosurgery is critical to balance oxygen carrying capacity (decreased by anemia). If the haematocrit is less which means less haemoglobin in the RBC , so more will flow to brain will be required to maintain oxygen supply to the brain and it will increase the intracranial pressure. It is one of the reason of headache I patients with anemia.
Patient temperature : mild hypothermia provides some protection against ischemia by reducing  CMRO2 by approximately 7% for each 1o C drop.

Head end elevation to 30 degree is good for reducing ICP. It facilitates venous return. Some surgeons use head end elevation to 30 degree as a routine but some use the flat end of upper part of OT table and opt for increase in head end elevation if there is need to reduce ICP or control of bleeding during surgery.


Inhalation agents reduce cerebral metabolism except nitrous oxide. They cause vasodilatation and increase cerebral blood volume (CBV) and ICP. And after 2 hours increase CSF which further increases ICP. Most agents increase the CO2 reactivity of cerebral blood vessels. 
The solubility of nitrous oxide ( N20) is 34 times that of nitrogen. When N2O comes out of solution in an airtight space it can increase the pressure which may convert pneumocephalus to “ tension pneumocephalus”. It may also aggravate air embolism. Thus caution must be used especially in the sitting position where significant post-op pneumocephalus and air embolism are common. The risk of tension pneumocephalus may be reduced by filling the cavity with fluid in conjunction with turning off N2O about 10 minutes prior to completion of dural closure.

Halogenated agents ( Isoflurane, desflurane, sevoflurane) suppress EEG activity and provide some degree of cerebral protection. Isoflurane can produce isoelectric EEG without metabolic toxicity. Desflurane, a cerebral vasodilator, increases CBF & ICP, decreases CMRO2 which tends to cause compensatory vasoconstriction. Sevoflurane increases CBP and ICP and reduces CMRO2 . Mild negative inotrope, cardiac output not as well managed as with isoflurane or desflurane.

Intravenous agents :
Propofol is used for induction & infusion during TIVA ( total intravenous anesthesia). Propofol causes dose dependent decrease in MAP & ICP.  It is more rapidly cleared than thiopental.

Barbiturates ( thiopental) reduce CMRO2 and scavenge free radicals.   Barbiturates produce dose dependent EEG suppression. Myocardial suppression & peripheral vasodilatation  can cause hypotension and can compromise CPP, especially in hypovolemic patients.

Etomidate, a carboxylated imidazole derivative. It is anesthetic & amnestic. Sometimes produces myoclonic activity which may be confused with seizures. It impairs renal function & should be avoided in patients with renal disease as it may produce renal insufficiency.

Ketamine, a NMDA receptor antagonist, produces dissociative anesthesia,. It may slightly increase heart rate & BP. As ketamine increases intracranial procedure,  ketamine is used less in neurosurgery as compared to short general surgical procedures in general surgery. 

Narcotics in Anesthesia

All narcotics cause dose dependent respiratory depression which can result in hypercarbia and concomitant increased ICP in non-ventilated patients.  Narcotics often contribute to post-operative nausea & vomiting (PONV).
Morphine
Meperidine ( Demerol)
Synthetic narcotics: Remifentanil, fentanyl, Sufentanil, Alfentanil
           Fentanyl crosses the blood brain barrier (BBB), reduces CMRO2, CBV, and so the intracranial pressure ( ICP). It is very commonly used drug in neurosurgery. It may be given as bolus and also as infusion.
           

Some other common drugs used in neuroanesthesia:
Benzodiazepines ( GABA agonists), decrease CMRO2, anticonvulsant action, produce amnesia.
Lidocaine
Esmolol
Dexmedetomidate: alpha 2 adrenergic receptor agonist, used for control of hypertension post operativelyality of awake craniotomy, either alone or with propofol. Also used to help patient tolerate endotracheal tube without sedatives/ narcotics to facilitate extubation.

Paralytics ( Neuromuscular blocking agents) for Intubation: to facilitate tracheal intubation, should be guided by neuromuscular twitch monitoring. Succinylcholine, rocuronium, vecuronium ( Norcuron), cisatracurium.
Intraoperative evoked potential monitoring
SSEP

Malignant hyperthermia
Malignant hyperthermia is a hypermetabolic state of skeletal muscle due to idiopathic block of Ca++ re-entry  into sarcoplasmic reticulum. Transmitted by multifactorail genetic predisposition. Total body oxygen consumption increases by 2 to 3 times.

Incidence 1/15000 in peds, 1 in 40,000 anesthetic administrations in adults. 50% had previous anesthesia without MH. Requently associated with administration of halogenated inhalational agents and the use of sucinylcholline ( fulminant form: muscle rigidity almost immediately after sucinylcholline, may invole masseters leading to difficulty in intubation).

Initial attack and recrudescence may occur post-op . 30% mortality.

Earliest sign increase in end-tidal pCO2, tachycardia or arrhythmia, DIC ( bleeding from surgical wound or body orifices), ABG ( metabolic acidosis), pulmonary edema, hyperthermia ( temp 44oC) at rate of 1o C/ 5 min, limb muscle rigidity, rhabdomyolysis ( increased CPK & myoglobin).

Terminal features are hypotension, bradycardia, and cardiac arrest.

Treatment: Eliminate offending agents ( stop the operation, discontinue inhalation agent and change tubing on anesthesia machine),

 Dantrolene sodium ( Dantrium) 2.5 mg/kg IV infusion till symptoms subside , upto 10 mg/kg

Hyperventilation with 100% oxygen

Surface and cavity cooling: IV, in wound, per NG , PR

Bicarbonate 1-2 mEq/kg for acidosis

IV insulin and glucose to lower K+, glucose acts as energy substrate

Procainamide for arrhythmia

Dieresis: volume loading and osmotic diuretic

Prevention: identification of patient at risk ( 4 cm muscle biopsy, abnormal contracture to caffeine or halothane), family history ( any relative), masseter response to succinycholine

Avoid  succinycholine, use non- halogenated anesthetic in patients at risk

Prophylactic oral dantrolene: 4-8 mg/kg/day for1-2 days ( last dose 2 hours before surgery)



How to interpret ABG ( arterial Blood Gases)? Easy!

pH less than 7 is acidic and more than 7 is alkaline.

To understand ABG you should know that normal pH of blood  is 7.40 plus or minus 0.04 ( So, In a normal person blood pH range is 7.36 to 7.44)

Normal range of partial pressure of the dissolved Carbon dioxide in arterial blood pCO2  is 25 mm Hg to 42 mm Hg. If a person hyperventilates then CO2 is washed out of the lungs and pCO2 falls, and on the contrary,  if a person’s respiratory hate is low, then there is CO2 retention and pCO2 rises.

ABG is very important investigation for neuroanesthetist and neurosurgeon. Because cerebral blood flow (CBF) , intracranial pressure ( ICP) and cerebral perfusion pressure ( CPP) are directly affected by pCO2. Dissolved in CO2 blood is the most potent stimulus for the control of respiratory rate and vasodilatation. If pCO2 rises the respiratory rate increases and there is cerebral vasodilatation and increase in CBF, CPP and ICP.

But neurosurgeons and neuroanesthetists are concerned about ICP and try to have optimum CBF, CPP and ICP. So, the respiratory rate should be appropriate. If respiratory rate is increased then CO2 washout from the lungs occur, pCO2 falls, vasoconstriction occurs and CBF and ICP is decreased. This is the principle and aim of elective hyperventilation , i.e., to reduce ICP by keeping pCO2 around and 25 mmHg (close to lower side of the normal range). This is a common practice for managing  patients with severe brain edema. But, if there is further reduction in pCO2 below 25 , then there may be vasoconstriction and brain ischemia. So, Monitoring of the patient on ventilator should be done with ABG, and accordingly the respiratory rate may be modified.

First check arterial pH, if pH is below 7.4 then it is acidosis and if pH is more than 7.4 then patient is having alkalosis.

If acidotic then check pCO2, if it is more than 40 mmHg then it is due to hypoventilation and patient is having Respiratory Acidosis. But if pCO2,  is less than 40 mmHg then it is metabolic acidosis and if anion gap is normal ( 8-12 meq/L) then diarrhea may be a cause of Metabolic Acidosis. If anion gap is increased , then renal failure, Lactic acidosis, diabetic ketoacidosis may be the cause of metabolic acidosis.

As mentioned earlier, if pH is more than 7.4 then patient is having alkalosis, which could either be due to respiratory or metabolic cause. So, check for pCO2, if it is less than 40 then patient may be hyperventilating and pCO2 washout is the cause and it is called Respiratory Alkalosis. Or, if patients pCO2 is more than 40 mmHg, then alkalosis is due to a metabolic cause and vomiting or diuretic use is  a common cause and is known as Metabolic Alkalosis.

Neurocritical care

The major challenges for the neuroanesthetists is not only limited to operation theatre but role is extended to neurosurgeical intensive care unit, where some issues are frequently encountered, like Hyponatremia
SIADH
Diabetes Insipidus
Pulmonary edema
Hypertension
Sedation
Elective hyperventilation

Commonest complaint at the time of intracranial neurosurgical intervention : Bulging brain
Commonest challenge in post-operative period: Raised ICP & deterioration of conscious level  due to raised Intra cranial pressure.
          Adequate brain relaxation facilitates neurosurgery and reduces the need for excessive brain retraction. Prolong and recessive brain reduces the blood supply to that particular ischemia which causes ischemia and which , in turn, increases brain edema. Sometimes, due to excessive brain swelling surgery is stopped and it becomes difficult to close the dura. So, enough precautions should be taken to avoid this situation. Cool temperature in the operation in the operation theatre is good for the patient.  Other measures include smooth intubation, proper positioning, padding of the pressure points, mild head end elevation, normal neck position to ensure proper venous drainage. Controlled ventilation with slight hypocapnia with target PaCO2 mm Hg induces cerebral vasoconstriction which consequently reduces brain edema.  So, continuous controlled ventilation without any interruption is mandatory during intracranial neurosurgery. Awakening of the patient or light anesthesia allowing movement of the patient, coughing & bucking  on the endotracheal tube create havoc during neurosurgery. This is very common complaint by any neurosurgeon. Excessive rotation at the neck during positioning may hamper venous return. Proper position of the pad below chest and pelvis ensures breathing movement, intrathoracic pressure and venous return and ICP.  Hyperventilation, head end elevation, Dexamethasone, Frusemide and intravenous Mannitol help in reducing brain edema.

  




Sources:


1. Handbook of Neurosurgery. Mark S. Greenberg, 7th Ed, Thieme, 2010
2. Ramamurthi & Tandon's Manual of Neurosurgery. Tandon PN, Ramamurthy R, Jain PKN, Jaypee Brothers medical Publishers
3. Chapter 6. Intra-operative monitoring written by Babu KS, Rajsekhar VRamamurthy & Tandon’s manual of Neurosurgery ,  Editors:  PN Tandon, Ravi Ramamurthy, Pradeep Kumar Jain N, first edition: 2014 ISBN 978-93-5152-192-1





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